Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-08-29
2006-08-29
Davis, Zinna N. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S118000
Reexamination Certificate
active
07098220
ABSTRACT:
Compounds of formula (I):wherein:R1represents hydrogen, halogen, alkyl, polyhaloalkyl, cyano, nitro, hydroxycarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl,R2represents hydrogen, alkyl, an optionally substituted aryl, optionally substituted heteroaryl, or R20—C(X)— wherein:R20represents alkyl, alkoxy, amino, alkylamino, dialkylamino, optionally substituted aryl or optionally substituted heteroaryl,X represents oxygen, sulphur, or NR21wherein R21represents hydrogen or alkyl,R3represents hydrogen atom or alkyl,n represents integer from 1 to 6 inclusive,the representationits enantiomers, diastereoisomers and also addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful as AMPK activators.
REFERENCES:
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Blache et al, Chemical Abstracts, vol. 131, Abstract No. 58803, 1999.
Minoru Oguchi, et al., “Molecular Design Synthsesis and Hypoglycemic activity of a series of Thiazolidine-2,4-diones” Journal of Medicinal Chemistry, 2000, Vo. 43(16), p. 3052-3066.
International Search Reprot: PCT FR2003 003277, Mar. 11, 2004.
International Preliminary Examination Report: PCT FR 2003 003277, May 19, 2004.
Bizot-Espiard Jean-Guy
Caignard Daniel-Henri
Kopp Marina
Lancelot Jean-Charles
Pfeiffer Bruno
Davis Zinna N.
Hueschen and Sage
Les Laboratoires Servier
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