Imidazopyridine derivatives for the treatment of hypertension

Details Imidazopyridine derivatives for the treatment of hypertension Imidazopyridine derivatives for the treatment of hypertension

1993-05-10

1995-06-13

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546118, A61K 3144, C07D47114

Patent

active

054243165

ABSTRACT:
An imidazopyridine derivative is disclosed of the formula [I]: ##STR1## wherein R.sup.1 is lower alkyl, R.sup.2 is hydrogen, lower alkylsulfonyl or a group of the formula ##STR2## where Z is oxygen or two hydrogen atoms, R.sup.0 is lower alkyl, lower alkoxy, phenyl, hydrogen, di(lower alkyl) amino or lower alkenyl, R.sup.3 is carboxyl or lower alkoxycarbonyl and Ring A is substituted phenyl, and pharmaceutically acceptable salts thereof that are useful in prophylaxis and treatment of hypertension.

REFERENCES:
patent: 4812462 (1989-03-01), Blankley et al.
patent: 4816463 (1989-03-01), Blankley et al.
patent: 5091390 (1992-02-01), Ardecky et al.
Journal of Heterocyclic Chemistry, vol. 28, pp. 97-108 (1991); S. Klutchko et al.
C. J. Blankley et al., Journal of Medicinal Chemistry; vol. 34, No. 11, (Nov. 1991); pp. 3248-3260.

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