Imidazopyridine-derivatives as inductible no-synthase...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S118000

Reexamination Certificate

active

07468377

ABSTRACT:
The compounds of Formula (I)in which R1, R2, R3, R4, R5 and A have the meanings as given in the description are novel effective iNOS inhibitors.

REFERENCES:
patent: 4045564 (1977-08-01), Berntsson et al.
patent: 7138399 (2006-11-01), Ulrich
patent: 7279484 (2007-10-01), Yamada et al.
patent: 25 04 252 (1975-08-01), None
patent: 0 125 756 (1984-11-01), None
patent: 97/25030 (1997-07-01), None
patent: 00/49015 (2000-08-01), None
patent: 03/080607 (2003-10-01), None
patent: 2005/030768 (2005-04-01), None
patent: 2005/030769 (2005-04-01), None
patent: 2005/030770 (2005-04-01), None
patent: 2005/061496 (2005-07-01), None
Dugas et al., Cytokine, Vol. 15, 2001, pp. 96-107.
Hua, L.L., et al., “Role of mitogen-activated protein kinases in inducible nitric oxide synthase and TNFα expression in human fetal astrocytes”,Journal of Neuroimmunology,Vol. 126, pp. 180-189, (2002).
Kim, M-S, et al., “Water-soluble chitosan inhibits the production of pro-inflammatory cytokine in human astrocytoma cells activated by amyloid β peptide and interleukin-1β”,Neuroscience Letters,Vol. 321, pp. 105-109, (2002).
D'Agostino, P., et al., “Tetracycline inhibits the nitric oxide synthase activity induced by endotoxin in cultured murine macrophages”,European Journal of Pharmacology,Vol. 346, pp. 283-290, (1998).
Kiss, J., et al., “Time-dependent actions of nitric oxide synthase inhibition on colonic inflammation induced by trinitrobenzene sulphonic acid in rats”,European Journal of Pharmacology,Vol. 336, pp. 219-224, (1997).
Sautebin, L., “Prostaglandins and nitric oxide as molecular targets for anti-inflammatory therapy”,Fitoterapia,Vol. 71, pp. S48-S57, (2000).
Ohtsuka, M., et al., “PPA250 [3-(2,4-Difluorophenyl)-6-{2-[4-(1H-imidazol-1-ylmethyl)Phenoxy]ethoxy}-2-phenylpyridine], a Novel Orally Efffective Inhibitor of the Dimerization of Inducible Nitric-Oxide Synthase, Exhibits an Anti-Inflammatory Effect in Animal Models of Chronic Arthritis”,The Journal of Pharmacology and Experimental Therapeutics,Vol. 33, No. 1, pp. 52-57, (2002).
Hansel, T. T., et al., “A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics”,FASEB J,Vol. 17, pp. 1298-1300, (2003).
Tinker, A. C., et al., “1,2-Dihydro-4-quinazolinamines: Potent, Highly Selective Inhibitors of Inducible Nitric Oxide Synthase Which Show Antiinflammatory Activity in Vivo”,J. Med. Chem.,Vol. 46, pp. 913-916, (2003).
Kankuri, E., et al., “Suppression of Acute Experimental Colitis by a Highly Selective Inducible Nitric-Oxide Synthase Inhibitor,N-[3-(Aminomethyl)benzyl]acetamidine”,The Journal of Pharmacology and Experimental Therapeutics,Vol. 298, No. 3, pp. 1128-1132, (2001).
Liu, Z-Q, et al., “Specificity of inducible nitric-oxide synthase inhibitors: prospects for their clinical therapy”,Acta Pharmacol Sin,Vol. 20, No. 11, pp. 1052-1056, (1999).
Salvemini, D., et al., “Dual Inhibition of Nitric Oxide and Prostaglandin Production Contributes to the Antiinflammatory Properties of Nitric Oxide Synthase Inhibitors”,J. Clin. Invest.,Vol. 96, pp. 301-308, (1995).
Cuzzocrea, S., et al., “Beneficial effects of GW274150, a novel, potent and selective inhibitor of INOS activity, in a rodent model of collagen-induced arthritis”,European Journal of Pharmacology,Vol. 453, pp. 119-129, (2002).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Imidazopyridine-derivatives as inductible no-synthase... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imidazopyridine-derivatives as inductible no-synthase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazopyridine-derivatives as inductible no-synthase... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4024562

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.