Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-10-09
2007-10-09
Seaman, Margaret D. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S126000
Reexamination Certificate
active
10573202
ABSTRACT:
The compounds of Formula (I)in which R1, R2, R3, R4, R5 and A have the meanings as given in the description are novel effective iNOS inhibitors.
REFERENCES:
patent: 4045564 (1977-08-01), Berntsson et al.
patent: 7138399 (2006-11-01), Ulrich
patent: 25 04 252 (1975-08-01), None
patent: 0 125 756 (1984-11-01), None
patent: 97/25030 (1997-07-01), None
patent: 00/49015 (2000-08-01), None
patent: 03/080607 (2003-10-01), None
patent: 2005/030768 (2005-04-01), None
patent: 2005/030769 (2005-04-01), None
patent: 2005/030771 (2005-04-01), None
patent: 2005/061496 (2005-07-01), None
Lidia et al., Fitoterapia, “Prostaglandins and nitric oxide as molecular targets for anti-inflammatory therapy”, 2000, vol. 71, pp. S48-S57.
Hua, L.L., et al., “Role of mitogen-activated protein kinases in inducible nitric oxide synthase and TNFα expression in human fetal astrocytes”,Journal of Neuroimmunology, vol. 126, pp. 180-189, (2002).
Kim, M-S, et al., “Water-soluble chitosan inhibits the production of pro-inflammatory cytokine in human astrocytoma cells activated by amyloid β peptide and interleukin-1β”,Neuroscience Letters, vol. 321, pp. 105-109, (2002).
D'Agostino, P., et al., “Tetracycline inhibits the nitric oxide synthase activity induced by endotoxin in cultured murine macrophages”,European Journal of Pharmacology, vol. 346, pp. 283-290, (1998).
Kiss, J., et al., “Time-dependent actions of nitric oxide synthase inhibition on colonic inflammation induced by trinitrobenzene sulphonic acid in rats”,European Journal of Pharamacology, vol. 336, pp. 219-224, (1997).
Cuzzocrea, et al., “Beneficial effects of GW274150, a novel, potent and selective inhibitor of iNOS activity, in a rodent model of collagen-induced arthritis”, Eur. J. Pharm., 453 (2002), pp. 119-129.
Salvemini, et al., “Dual inhibition of Nitric Oxide and Prostaglandin Production Contributes to the Antiinflammatory Properties of Nitric Oxide Synthase Inhibitors”, J. Clin. Invest., 96 (1995), pp. 301-308.
Liu, et al., “Specificity of inducible nitric-oxide synthase inhibitors: prospects for their clinical therapy”,Acta Pharmacol. Sin, 20 (11), 1999, pp. 1052-1056.
Kankuri, et al. “Suppression of Acute Experimental Colitis by a Highly Selective Inducible Nitric-Oxide Synthase Inhibitor,N-[3-(Aminomethyl)benzyl]acetamidine”, JPET, 298 (2001), pp. 1128-1132.
Tinker, et al., “1,2-dihydro-4-quinazolinamines: Potent Highly Selective Inhibitors of Inducible Nitric Oxide Synthase Which Show Antiinflammatory Activity in vivo”,J. Med. Chem., 46 (2003), pp. 913-916.
Ohtsuka, et al., “PPA250 {3-(2, 4-difluorophenyl)-6-{2-[4-(1H-imidazol-1-ylmethyl) Phenoxy]ethoxy}-2-phenylpyridine], a Novel Orally Effective Inhibitor of the Dimerization of Inducible Nitric-Oxide Synthase, Exhibits an Anti-Inflammatory Effect in Animal Models of Chronic Arthritis”,JPET, 303 (2002), pp. 52-57.
Hansel, et al., “A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics”,FASEB J, 17 (2003), pp. 1298-1300.
Goldberg Joshua B.
McGee Sheldon M.
Nycomed GmbH
Rahmani Niloofar
Seaman Margaret D.
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