Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-06-20
2006-06-20
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S347100
Reexamination Certificate
active
07064142
ABSTRACT:
Compounds represented by the general formula (I):wherein Ar1and Ar2are each aryl or heteroaryl; R1is lower cycloalkyl, —Ar3, or a group of the general formula (a), (b) or (c):and R2and R3are each hydrogen, lower cycloalkyl, lower alkenyl, or optionally substituted lower alkyl (with the proviso that when R2and R3are simultaneously hydrogen, Ar1, Ar2and R1do not simultaneously represent unsubstituted phenyl). The compounds are useful as treating agents for various NPY-related diseases, for example, circulatory diseases including hypertension, kidney diseases, cardiac diseases, vasospasm and arteriosclerosis; central nervous system diseases including hyperphagia, depression, anxiety, convulsion, epilepsy, dementia, pain, alcohol dependence, and withdrawal symptoms due to abstinence from drugs; metabolic diseases including obesity, diabetes, hormonal disorders, hypercholesterolemia, and hyperlipidemia; sexual dysfunction and reproductive function disorders; digestive diseases including enterokinetic disorders; respiratory diseases; inflammation; or glaucoma.
REFERENCES:
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Chemical Abstracts, vol. 52, No. 17240f.
Database, Accession No. 27672, XP002227829 “abstract”.
S. Wey et al., “Preparation of Primary Vicinal Diamines from Amino Acid Esters and Crystal Structure of a Chiral Nickel Salen Complex”, Tetrahedron Letters, vol. 12, No. 34, pp. 1905-1908, 1993.
R. Granger et al., vol. 250, No. 2, Apr. 4, 1960, pp. 2581-2583, XP002082608.
Fukami Takehiro
Ishihara Akane
Ishii Yasuyuki
Jitsuoka Makoto
Kanatani Akio
Banyu Pharmaceutical Co. Ltd.
Saeed Kamal A.
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