Imidazolylphenol compounds, pharmaceutical compositions containi

Details Imidazolylphenol compounds, pharmaceutical compositions containi Imidazolylphenol compounds, pharmaceutical compositions containi

1993-02-17

1994-10-18

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514399, 514826, 5483151, 5483154, 5483381, 5483385, A61K 31535, C07D23360

Patent

active

053569210

ABSTRACT:
3- and 4-(1H-imidazol-1-yl)phenol compounds corresponding to the formula I ##STR1## in which R.sup.1 represents NH.sub.2 or CH.sub.3, R.sup.2 represents H or CH.sub.3, X represents O or S, Y represents H, OH or OCH.sub.3, and Z represents --CH.dbd.CH--, O or S, or their salts, which exhibit 5-lipoxygenase and thromboxane synthase inhibiting activities.

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patent: 4665080 (1987-05-01), Wess et al.
European Search Report, Den Haag, completed May 10, 1993.
Tai et al., "On the Inhibitory Potency of Imidazole and its Derivatives on Thrombboxane Synthetase", Biochem. and Biophys. Res. Comm., vol. 80, No. 1, pp. 236-242 (1978).
Summers et al., "Orally Active Hydroxamic Acid Inhibitors of Leukotriene Biosynthesis", J. Med. Chem., vol. 31, No. 1, pp. 3-5 (1988).
Tanaka et al., "Studies on Furan Derivatives, XII.", J. Heterocyclic Chem., vol. 18, pp. 1241-1244 (1981).
Meerwein, Methoden der Organischen Chemie, Fourth Edition, vol. 6/3, pp. 85-90 Houben-Weyl, Stuttgart (1965).

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