(Imidazolylmethyl)pyridine compounds as thromboxane synthetase i

Details (Imidazolylmethyl)pyridine compounds as thromboxane synthetase i (Imidazolylmethyl)pyridine compounds as thromboxane synthetase i

1980-11-20

1982-07-13

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544131, 546276, 546278, 42424851, 42424854, 424263, C07D40106, C07D40100, C07D41300

Patent

active

043395830

ABSTRACT:
Certain 2-(1-imidazolylmethyl)pyridine compounds, having a further substituent O--Y--Z at the 3- or 5-position of the pyridine ring. Y is --(CH.sub.2).sub.n --, --CH.sub.2 C.sub.6 H.sub.4 --, or --CH.sub.2 (Het)--, where n is an integer from 1 to 4 and Het is a heterocyclic group; Z is a carboxy (COOH) or carboxycarbonyl (COCOOH) group, or an ester or amide derivative thereof. The compounds of the invention selectively inhibit the thromboxane synthetase enzyme, without significantly inhibiting the action of the prostacyclic or cyclo-oxygenase enzymes in animals, including man. The compounds are useful, therefore, in the treatment of thrombosis, ischaemic heart disease, stroke, transient ischaemic attack, migraine and the vascular complications of diabetes.

REFERENCES:
patent: 3417091 (1968-12-01), Pickholz et al.
patent: 4058614 (1977-11-01), Baldwin
patent: 4177350 (1979-12-01), Zirngibl et al.
patent: 4230714 (1980-10-01), Cross et al.

Affiliated with

Also associated with

Rating

(Imidazolylmethyl)pyridine compounds as thromboxane synthetase i does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with (Imidazolylmethyl)pyridine compounds as thromboxane synthetase i, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and (Imidazolylmethyl)pyridine compounds as thromboxane synthetase i will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-204751