Imidazolylmethyl methanobenzazocines

Details Imidazolylmethyl methanobenzazocines Imidazolylmethyl methanobenzazocines

1977-02-28

1978-08-22

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D22126

Patent

active

041088573

ABSTRACT:
1,2,3,4,5,6-Hexahydro-3-(Y)-6-(R.sup.1)-11-(R.sup.2)-2,6-methano-3-benzazoc ines, wherein Y is cycloalkyl-lower alkyl, lower alkyl-cycloalkyl-lower alkyl, carboxy-lower alkyl, cyano-lower alkyl, carbamyl-lower alkyl, tetrahydrofurylmethyl, 2-(2- or 3-indolyl)ethyl, amino-lower alkyl, butylcarbamyl, pyridinecarbonyl, (1-lower alkyl-imidazol-5-yl)methyl, 2,2-dimethoxyethyl, lower alkenyl, halo-lower alkenyl or cyano-lower alkenyl, R.sup.1 is lower alkyl and R.sup.2 is hydrogen or lower alkyl, are obtained starting with the corresponding 3-(H) compounds, in some instances via 3-acylated intermediate amides. The products have useful central depressant and psychomotor action, the preferred species wherein Y is cycloalkyl-lower alkyl or lower alkylcycloalkyl-lower alkyl being useful as analgesic agents in humans.

REFERENCES:
patent: 2924603 (1960-02-01), Gordon et al.

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