Imidazolylethoxymethyl derivatives of pyrazole

Details Imidazolylethoxymethyl derivatives of pyrazole Imidazolylethoxymethyl derivatives of pyrazole

1979-12-20

1981-02-03

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548336, A01N 4350, C07D40300

Patent

active

042488818

ABSTRACT:
Compounds are provided having the structure ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each may be hydrogen, lower alkyl, phenyl-lower alkyl, phenyl, substituted phenyl wherein the phenyl group bears one halogen, hydroxy, lower alkyl, lower alkylthio, cyano or nitro group; R.sup.3 is halogen; and R.sup.4 and R.sup.5 may be the same or different and each may be hydrogen, hydroxy, lower alkoxy, lower alkylthio or halogen.
These compounds as well as acid addition salts thereof are useful as antimicrobial agents.

REFERENCES:
patent: 3658813 (1972-04-01), Godefroi et al.
patent: 3717655 (1973-02-01), Godefroi et al.
patent: 3991201 (1976-11-01), Heeres et al.
patent: 4059705 (1977-11-01), Walker
patent: 4062966 (1977-12-01), Gymer
patent: 4107314 (1978-08-01), Cox et al.
patent: 4159380 (1979-06-01), Hoehn
Chem. Abstracts 76: 72516q.
Godefroi et al., J. Med. Chem. 12, pp. 784-791 (1969).
Heeres et al., J. Med. Chem. 19(9), pp. 1148-1155 (1976).
Heeres et al., J. Med. Chem. 20(11), pp. 1511-1520 (1977).
Walker, J. Med. Chem. 21(12), pp. 1335-1338 (1978).

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