Imidazolylalkylthioalkylamino-ethylene derivatives

Details Imidazolylalkylthioalkylamino-ethylene derivatives Imidazolylalkylthioalkylamino-ethylene derivatives

1978-09-26

1980-04-29

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

260465E, 2604655R, 260558S, 260561A, 2605705C, 2605705P, 2605705S, 260583EE, 560 16, 560 17, 560147, 560153, 424273R, C07D23364

Patent

active

042007607

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive; R.sup.2 is hydrogen, (lower)alkyl, halogen or hydroxymethyl; m is 1 or 2, and n is 2 or 3, provided that the sum of m and n is 3 or 4; X and Y each are independently hydrogen, nitro, cyano, --SO.sub.2 Ar or --COR.sup.3, provided that X and Y are not both hydrogen; R.sup.3 is (lower)alkyl, Ar, (lower)alkoxy, amino or (lower)-alkylamino; and Ar is an optionally substituted phenyl group; and nontoxic pharmaceutically acceptable acid addition salts thereof, are potent anti-ulcer agents. Processes for their preparation and novel intermediates are also disclosed.

REFERENCES:
patent: 3932443 (1976-01-01), White
patent: 3953460 (1976-04-01), Durant et al.
patent: 3968227 (1976-07-01), Durant et al.
patent: 4013678 (1977-03-01), Brown et al.
patent: 4028379 (1977-06-01), White
patent: 4049671 (1977-09-01), Durant et al.
patent: 4098898 (1978-07-01), Durant et al.
patent: 4112234 (1978-09-01), Crenshaw et al.
Drugs of the Future 1976, vol. 1, No. 1, pp. 13-18.
Ganellin et al., Federation Proceedings 1976 , vol. 35, pp. 1924-1930.

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