Imidazolyl vinyl ethers and process for preparing same

Details Imidazolyl vinyl ethers and process for preparing same Imidazolyl vinyl ethers and process for preparing same

1978-12-18

1980-07-01

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

542405, 542411, 542413, 542426, 542453, 542458, A61K 31415, C07D23360

Patent

active

042106567

ABSTRACT:
.alpha.-Aryl-.beta.-imidazol-1-yl vinyl ethers and their acid addition salts are disclosed, wherein the imidazolyl vinyl ether has the formula: ##STR1## Ar represents a substituted or unsubstituted aryl group, R an alkyl, aryl or aralkyl group, X an oxygen atom, a sulfur atom, a sulfinyl or a sulfonyl group and R1 a lower alkyl group or a nitro group. These compounds are effective wide spectrum fungicides and bactericides. To prepare these vinyl ethers, a corresponding 1-arylacylimidazole is o-alkylated in presence of NaH with a corresponding .alpha.-halogen ether, .alpha.-halogen thioether, .alpha.-halogen sulfinyl compound or a corresponding .alpha.-halogen sulfonyl compound.

REFERENCES:
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patent: 3658797 (1972-04-01), Ross et al.
patent: 3658813 (1972-04-01), Godefroi et al.
patent: 3839574 (1974-10-01), Godefroi et al.
patent: 4086351 (1978-04-01), Batasubramanyan
Buehler et al., Survey of Organic Syntheses, vol. 2, pp. 335-344, N.Y., Wiley, 1977.
Gross et al., Angew. Chem., 1967, vol. 79, pp. 358-362.
Shostakovskii et al., Russian Chem. Rev., 1968, vol. 37, pp. 907-919.
Summers, Chem. Rev., 1955, vol. 55, pp. 301, 314-317 & 336-338.
Hofmann, Imidazoles and Its Derivatives Part I, p. 127, N.Y., Interscience, 1953.
Godefroi et al., J. Med. Chem., 1969, vol. 12, pp. 784-791.

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