Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-01-08
2008-01-08
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S300100
Reexamination Certificate
active
07317032
ABSTRACT:
The present invention provides imidazolyl inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such compounds and compositions.
REFERENCES:
patent: 6723743 (2004-04-01), Thurkauf et al.
patent: 6884815 (2005-04-01), Thurkauf et al.
patent: 6927227 (2005-08-01), Robl et al.
ARKAT USA Journal, vol. 2003, published Jan. 28, 2003, compound 24.
U.S. Appl. No. 10/932,981, filed Sep. 1, 2004, Ngu et al.
U.S. Appl. No. 10/932,457, filed Sep. 1, 2004, Weinstein.
Bleich, D., et al., “Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice”, The Journal of Clinical Investigation, vol. 103, No. 10, pp. 1431-1436, May 1999.
Bocan, T., et al., “A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophase enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit”, Atherosclerosis, vol. 136, pp. 203-216, 1998.
Kelavkar, U. et al., “The Effect of 15-Lipoxygenase -1 Expression on Cancer Cells”, Current Urology Reports, vol. 3, pp. 207-214, 2002.
Setty, B.N., et al., 15-Hydroxyeicosatetraenoic Acid-Medicated Potentiation of Thrombia-Induced Platelet Functions Occurs Via Enhanced Production of Phosphoinositide-Derived Second Messengers—sn-1,2-Diacylglycerol and Inositol-1,4,5-Trisphosphate, Blood., vol. 80, No. 11, pp.
Sultana, S., et al., “Lipoxygenase Metabolites Induced Expression of Adhesion Molecules and Transendothelial Migration of Monocyte-Like HL-60 Cells Is Linked to Protein Kinase C Activation”, Journal of Cellular Physiology, vol. 167, pp. 477-487, 1996.
Tisdale, M.J., “Protein Loss in Cancer Cachexia”, Science's Compass, vol. 289, pp. 2293-2294. 2000.
Ngu Khehyong
Robl Jeffrey A.
Weinstein David S.
Bristol-Myers Squibb Co.
Chung Susannah
Gibbons Maureen S.
Saeed Kamal A.
LandOfFree
Imidazolyl inhibitors of 15-lipoxygenase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Imidazolyl inhibitors of 15-lipoxygenase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazolyl inhibitors of 15-lipoxygenase will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2812398