Imidazolyl derivatives as corticotropin releasing factor...

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S082000, C546S084000, C546S118000, C546S273100, C548S250000, C548S258000, C548S262400, C548S303100, C514S259300, C514S267000, C514S293000, C514S303000, C514S393000

Reexamination Certificate

active

10767645

ABSTRACT:
The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF receptor”)useful for the treatment of depression, anxiety, affective disorders, feeding disorders, post-traumatic stress disorder, headache, drug addiction, inflammatory disorders, drug or alcohol withdrawal symptoms and other conditions the treatment of which can be effected by the antagonism of the CRF-1 receptor.

REFERENCES:
patent: 0 778 277 (1997-06-01), None
patent: 0 812 831 (1997-12-01), None
patent: 0 902 029 (1999-03-01), None
patent: 0 970 958 (2000-01-01), None
patent: WO 97/29109 (1997-08-01), None
patent: WO 98/35967 (1998-08-01), None
patent: WO 99/01454 (1999-01-01), None
patent: WO 99/10350 (1999-03-01), None
patent: WO 99/67247 (1999-12-01), None
patent: WO 00/01675 (2000-01-01), None
patent: WO 00/01697 (2000-01-01), None
patent: WO 00/39127 (2000-07-01), None
patent: WO 00/59907 (2000-10-01), None
patent: WO 00/59908 (2000-10-01), None
patent: WO 01/007440 (2001-02-01), None
March, J. Advanced Organic Chemistry—Reactions, Mechanisms, and Structure, 4thEdition, (c) 1992, John Wiley & Sons, New York, NY, pp. 308-313.
Dunn, et al., “Physiological and behavioral response to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?”, Brain Research Reviews, 15, 1990, pp. 71-100.
Gulyas, et al., “Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor,” Prac. Natl. Acad. Sci. USA, 92, 1995, pp. 10575-10579.
McCarthy, et al., “Recent Advances with the CRF1 Receptor: Design of Small Molecule Inhibitors, Receptor Subtypes and Clinical Indications,” Current Pharmaceutical Design, 5, 1999, pp. 289-315.
Holsboer, “The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety,” Journal of Psychiatric Research, 33, 1999, pp. 181-214.
Banki, et al., “CSF corticotropin-releasing hormone and somatostatin in major depression: response to antidepressant treatment and relapse,” European Neuropsychopharmacology, 2, 1992, pp. 107-113.
Zobel, et al., “Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression, the first 20 patients treated,” Journal of Psychiatric Research, 34, 2000, pp. 171-181.
Webster, et al., “Corticotropin-Releasing Hormone and Inflammation,” Annals New York Academy of Sciences, 840, 1998, pp. 21-62.
Gilligan, et al., “Corticotropin Releasing Factor (CRF) Receptor Modulators: Progress and Opportunities for New Therapeutic Agents,” Journal of Medicinal Chemistry, 43, 9, 2000, pp. 1641-1660.
McCarthy, et al., “Chapter 2. Recent Progress in Corticotropin-Releasing Factor Receptor Agents,” Annual Reports in Medicinal Chemistry, 34, 1999, pp. 11-20.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Imidazolyl derivatives as corticotropin releasing factor... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imidazolyl derivatives as corticotropin releasing factor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazolyl derivatives as corticotropin releasing factor... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3733191

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.