Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dih

Details Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dih Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dih

1993-07-16

1996-05-07

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514332, 514255, 514318, 546263, 546278, 546194, 544365, A61K 3144, C07D40110

Patent

active

055146937

ABSTRACT:
Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydropyridines of formula (I) ##STR1## wherein Het is ##STR2## A represents a direct linkage, --CH.sub.2 --, CH.sub.2 --CH.sub.2 -- or, when Het is ##STR3## A may also represent --CH.dbd.CH--; R is hydrogen, halogen, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy; each of R.sub.3 and R.sub.4 is a C.sub.1 -C.sub.3 alkyl group; one of R.sub.1 and R.sub.2 is a group --OR' wherein R' is a C.sub.1 -C.sub.6 alkyl either unsubstituted or omega substituted by C.sub.1 -C.sub.3 alkoxy or cyano, and the other is, independently,

REFERENCES:
patent: 3946028 (1976-03-01), Bossert
patent: 4492703 (1985-01-01), Goldmann
patent: 4599341 (1986-07-01), Halczenko et al.
patent: 4766213 (1988-08-01), Juraszyk et al.
J. Med. Chem. 1993, 36, pp. 2964-2972, P. Cozzi, et al., "Imidazol-1-YL and Pyridin-3-YL Derivatives of 4-Phenyl-1,4-Dihydropyridines Combining CA2+ Antagonism and Thromboxane A2 Synthase Inhibition".
Poster Presentation, Oct. 1990, Congresso della Societa Italiana di Farmacologia, Taormina; "FCE 24265: UN Calcio Antagonista Inibitore Della Sintesi Del Trombossano"; F. Vaghi, et al.
8th Carmerino-Noordwijkerhout Symposium, Camerino, 1991; "Imidazolyl And Pyridil Derivatives Of 1,4-Dihydropyridines Combining Ca-Antagonism And TxA.sub.2 Synthase Inhibition"; P. Cozzi, et al.

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