Imidazolyl-(2)-carbinols having hypolipidemic action and process

Details Imidazolyl-(2)-carbinols having hypolipidemic action and process Imidazolyl-(2)-carbinols having hypolipidemic action and process

1979-01-24

1980-07-22

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424273B, 548327, 548330, 548331, 548336, 548342, 548343, 548345, A61K 31415, C07D23364, C07D23512

Patent

active

042139945

ABSTRACT:
Pharmaceutical preparations having hypolipidemic activity, which contain in addition to a pharmaceutically acceptable carrier an effective amount of an imidazolyl-(2)-carbinol of the general formula I ##STR1## in which R represents hydrogen, lower alkyl, phenyl or benzyl, R.sub.1 and R.sub.2 each represent hydrogen or together the group --CH.dbd.CH--CH.dbd.CH--, R.sub.3 and R.sub.4 represent hydrogen, lower alkyl, phenyl, lower haloalkyl, lower alkylphenyl, lower alkoxyphenyl, lower haloalkoxyphenyl, mono- or dihalophenyl, imidazolyl or benzylimidazolyl or R.sub.3 and R.sub.4 are together fluoryl of the formula ##STR2## or of a physiologically tolerable acid addition salt thereof, and process for preparing them.

REFERENCES:
patent: 3652579 (1972-03-01), Hoffer et al.
patent: 3812189 (1974-05-01), Pollard et al.
Behringer et al., Chem. Ber. 1966, vol. 99, pp. 1815-1821.
Rohr et al., Chem. Ber. 1968, vol. 101, pp. 3491-3498.
Roe J. Chem. Soc. (London) 1963, pp. 2195-2200.
Shirley et al., J. Amer. Chem. Soc. 1957, vol. 79, pp. 4922-4927.
Tertov et al., Chem. Abst. 1971, vol. 74, No. 76466e.
Lawesson et al., Tetrahedron 1968, vol. 24, pp. 1875-1888.
O'Sullivan et al., I Chem. Abst. 1964, vol. 60, col. 10669.
O'Sullivan et al., II Experienta 1971, vol. 27, pp. 1025-1027.
Otaki et al., J. Pharm. Soc. Japan 1965, vol. 85, pp. 926-935.
Sinnur et al., Chem. Abst. 1966, vol. 65, col. 12192.
Zellner et al., Monatsh. Chem. 1967, vol. 98, pp. 643-665.

Affiliated with

Also associated with

Rating

Imidazolyl-(2)-carbinols having hypolipidemic action and process does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imidazolyl-(2)-carbinols having hypolipidemic action and process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazolyl-(2)-carbinols having hypolipidemic action and process will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2178471