Imidazolophthalazine derivatives as ligands for GABAA receptors

Details Imidazolophthalazine derivatives as ligands for GABAA receptors Imidazolophthalazine derivatives as ligands for GABAA receptors

2005-09-20

2005-09-20

Bernhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S248000, C544S115000, C544S234000

Reexamination Certificate

active

06946461

ABSTRACT:
A class of substituted imadazolo[2,1-a]phthalazine derivatives as ligands for GABAAreceptors of formula I:which are partial or full inverse agonists of an α5 receptor subunit while being relatively free of activity at α1 and/or α2 and/or α3 receptor subunit binding sites are described herein; they are therefore of benefit as a medicament for enhancing cognition but with the reduction or elimination of proconvulsant activity.

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Maubach, Medline Abstract for Current Drug Targets-CNS & Neurological Disorders, vol. 2, p. 233-239 (2003).
Chemical Abstracts, vol. 119, No. 15, Oct. 11, 1993 Catarzi, D. et al, p. 22; col. 1; XP002179824 abstract & IL Farmaco, vol. 48, No. 4, 1993, pp. 447-457.

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