Imidazolones and their use in treating benign prostatic hyperpla

Details Imidazolones and their use in treating benign prostatic hyperpla Imidazolones and their use in treating benign prostatic hyperpla

1998-12-17

2000-04-04

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

514255, 514341, 546210, C07D40300, C07D41100, A61K 31495, A61K 3144

Patent

active

060463317

ABSTRACT:
This invention is directed to imidazolones which are selective antagonists for human .alpha..sub.1a receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia, sympathetic mediated pain, migraine, and for the treatment of any disease where the antagonism of the .alpha..sub.1a receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

REFERENCES:
patent: 5227486 (1993-07-01), Merce-Vidal et al.
patent: 5731331 (1998-03-01), Merce-Vidal et al.
patent: 5760234 (1998-06-01), Yuan et al.
patent: 5776937 (1998-07-01), Gante et al.
patent: 5872136 (1999-02-01), Anthony et al.

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