Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-01-18
1991-10-22
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546210, 544370, 514326, A61K 31495, A61K 31445, C07D40300, C07D40100
Patent
active
050596012
ABSTRACT:
Invention concerns 4,5-bisubstituted-2-imidazolone derivatives of formula I ##STR1## and pharmaceutically acceptable salts thereof, having high affinity in vitro for D.sub.2, 5-HT.sub.2, .sub.1 receptors and in vivo activity on central nervous system and antihypertensive activity with negligible secondary effects; methods for the preparation thereof; pharmaceutical formulations containing them.
REFERENCES:
patent: 4329471 (1982-05-01), Grisar
patent: 4381393 (1983-04-01), Grisar
patent: 4889864 (1989-12-01), Ehrhardt et al.
Cascio Giuseppe
Manghisi Elso
Salimbeni Aldo
Istituto Lusofarmaco d'Italia S.p.A.
Lee Mary C.
Schneider Walter H.
Whittenbaugh Robert C.
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