Imidazolone anorectic agents: III. heteroaryl derivatives

Details Imidazolone anorectic agents: III. heteroaryl derivatives Imidazolone anorectic agents: III. heteroaryl derivatives

1999-03-03

2000-08-01

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514256, 514341, 514380, 5142521, 544333, 544405, 5462741, 5462744, 548260, 5483124, 5483147, 5483151, 5483157, A61K 314166, C07D23370, C07D23924, C07D24110

Patent

active

060967455

ABSTRACT:
A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of heteroaryl derivatives of imidazolone compounds of Formula 1. ##STR1## As antagonists of NPY-induced feeding behavior, these compounds and known analogs are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

REFERENCES:
patent: 3894008 (1975-07-01), Irvine
Gehlert, et al., "Neuropeptide Y Receptor Antagonists in Obesity," Expert Opinion on Investigational Drugs, vol. 6, No. 12, Dec. 1997, pp. 1827-1838 .

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