Imidazolone anorectic agents: II. phenyl derivatives

Details Imidazolone anorectic agents: II. phenyl derivatives Imidazolone anorectic agents: II. phenyl derivatives

1999-03-03

2000-04-25

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514 585, 514214, 5142358, 5142278, 514255, 514341, 514359, 514395, 514397, 514398, 544139, 544310, 546210, 5483061, 5483117, 5483121, 5483147, 5483151, 5483154, 5483235, 5483241, 5483255, 540520, C07D23332, C07D23348, A61K 314166, A61K 314164

Patent

active

060545909

ABSTRACT:
A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of phenyl derivatives of imidazolone compounds of Formula I. ##STR1## As antagonists of NPY-induced feeding behavior, these compounds and known analogs are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

REFERENCES:
patent: 5213607 (1993-05-01), Guaciaro
Gehlert et al., "Neuropeptide Y Receptor Antagonists in Obesity," Expert Opinion on Investigational Drugs, vol. 6, No. 12, Dec. 1997, pp. 1827-1838 .

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