Imidazolinoxyl derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

5483481, 5483491, 5483511, 5483521, A61K 31415, C07D23324, C07D23322, C07D23320

Patent

active

055367445

ABSTRACT:
This invention offers the compounds which exhibit a coronary blood vessel dilating action which is long-acting.
(Constitution)
Novel imidazolinoxyl derivatives represented by a general formula (1). A compound A in which R is COOH is given in an example. ##STR1## (Merit) The compounds of the present invention can be directly administered, after diluting to a suitable concentration with a phosphate buffer or the like, to blood vessel which is required to be relaxed and dilated whereby a significant and long-acting relaxing action is resulted though, in a blood flow, they are quickly inactivated and excreted and no side effect is noted.

REFERENCES:
Tsunoda et al, "Vasodilator effect of carboxy, etc" Eur. J. Pharmacol. (1994), 262 (1-2), 55-63.
Yoshida et al, "Therapeutic effects of, etc" Biochem. Biophys. Res. Commun. (1994), 202(2), 923-30.
Woldman et al, "Spin Trapping of Nitric, etc" Biochem. Biophys. Res Commun (1994), 202(1), 195-203.

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