Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-12-23
1996-07-16
Morris, Patricia L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5483481, 5483491, 5483511, 5483521, A61K 31415, C07D23324, C07D23322, C07D23320
Patent
active
055367445
ABSTRACT:
This invention offers the compounds which exhibit a coronary blood vessel dilating action which is long-acting.
(Constitution)
Novel imidazolinoxyl derivatives represented by a general formula (1). A compound A in which R is COOH is given in an example. ##STR1## (Merit) The compounds of the present invention can be directly administered, after diluting to a suitable concentration with a phosphate buffer or the like, to blood vessel which is required to be relaxed and dilated whereby a significant and long-acting relaxing action is resulted though, in a blood flow, they are quickly inactivated and excreted and no side effect is noted.
REFERENCES:
Tsunoda et al, "Vasodilator effect of carboxy, etc" Eur. J. Pharmacol. (1994), 262 (1-2), 55-63.
Yoshida et al, "Therapeutic effects of, etc" Biochem. Biophys. Res. Commun. (1994), 202(2), 923-30.
Woldman et al, "Spin Trapping of Nitric, etc" Biochem. Biophys. Res Commun (1994), 202(1), 195-203.
Akaike Takaaki
Katayama Yoshiki
Maeda Hiroshi
Okumura Ken
Sasamoto Kazumi
Dojindo Laboratories
Morris Patricia L.
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