Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-01-19
1990-01-30
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548353, A61K 31415, C07D23322
Patent
active
048974129
ABSTRACT:
Antiglaucoma compounds having beta adrenoreceptor antagonist properties and alpha adrenoreceptor antagonist properties are described. The compounds comprise a beta blocker-derived moiety designed to provide beta antagonist properties and an imidazolidine moiety designed to provide alpha-antagonist properties. Methods of synthesizing the compounds are also described. The compounds are useful in the treatment of glaucoma due to their ability to lower elevated intraocular pressure.
REFERENCES:
patent: 4195085 (1980-03-01), Stone
patent: 4342783 (1982-08-01), Morselli et al.
patent: 4444782 (1984-04-01), DeMarinis et al.
patent: 4450170 (1984-05-01), Beeley et al.
patent: 4461904 (1984-07-01), York, Jr.
patent: 4515800 (1985-05-01), Carero et al.
patent: 4517199 (1985-05-01), York, Jr.
McGuinness et al., "Timolol and Dipivalyl Epinephrine Combination Therapy", Aus. J. of Oph. 10, pp. 179-182 (1982).
Weinreb et al., "Effect of Adding Betaxolol to Dipivefrin Therapy", Am J. of Oph., vol. 101, pp. 196-198 (1986).
LeClerc et al., "Agents Alpha-Adrenergigues Alcoylants", Eur. J. Med. Chem., 13, No. 6, pp. 521-526 (1978).
LeClerc et al., "Unusual Reaction of N-Hydroxyphthalimido Ethers Leading to Oxygen-Nitrogen Heterocycles", J. Org. Chem. 47, pp. 517-523 (1982).
Ehrhardt, J. D., "Metabolisme du catapressan Action hypotensive du 4-hydroxycatapressan", Therapie XXVII, pp. 947-954 (1972).
Barefield et al., "Synthesis and Stereochemistry of Cobalt (III) Complexes of 1,3-Diamino-2-Propanol and Related Ligands", Inorg. Chem., vol. 13, pp. 2611-2617 (1974).
Chem. Abstracts, 70 106522g (1969)[Hungary 155,329, 11/22/88].
LeClerc et al., "Syntheses et reactivite de la p-aminoclonidine" Bulletin de la Societe Chimique de France, No. 9-10, pp. II-520-528 (1979).
Andermann Guy
Himber Jacques
Huber Didier
LeClerc Gerard
Arno James A.
Brown Gregg C.
Laboratories Alcon S.A.
Schwartz Richard A.
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