Imidazolidyl rapamycin derivatives

Details Imidazolidyl rapamycin derivatives Imidazolidyl rapamycin derivatives

1993-03-05

1994-05-10

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D49818, A61K 31395

Patent

active

053109031

ABSTRACT:
Imidazolidyl rapamycin derivatives of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-42 and/or C-31. These compounds are useful in a mammalian host for the treatment of autoimmune diseases and diseases of inflammation, infectious diseases, the prevention of rejection of foreign organ transplants and the treatment of solid tumors.

REFERENCES:
patent: 3929992 (1975-12-01), Sehgal et al.
patent: 4650803 (1987-03-01), Stella et al.
patent: 5100883 (1992-03-01), Schiehser
patent: 5102876 (1992-04-01), Caufield
patent: 5118677 (1992-06-01), Caufield
patent: 5118678 (1992-06-01), Kao et al.
patent: 5120725 (1992-06-01), Kao et al.
patent: 5120727 (1992-06-01), Kao et al.
patent: 5120842 (1992-06-01), Failli et al.
patent: 5138051 (1992-08-01), Hughes et al.
patent: 5151413 (1992-09-01), Caufield et al.
patent: 5162333 (1992-11-01), Failli et al.
patent: 5162334 (1992-11-01), Goulet et al.
patent: 5169851 (1992-12-01), Hughes et al.
Findlay, et al., Can. J. Chem., 58, 579-590 (1980).

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