Imidazolidyl macrolides having immunosuppressive activity

Details Imidazolidyl macrolides having immunosuppressive activity Imidazolidyl macrolides having immunosuppressive activity

1993-09-20

1994-09-06

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D49116, A61K 31395

Patent

active

053449258

ABSTRACT:
Imidazolidyl macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.

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Thompson, et al., Springer Semin. Immunopathol., 14, 323-344 (1993).

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