Imidazolidyl macrolides having immunosuppressive activity

Details Imidazolidyl macrolides having immunosuppressive activity Imidazolidyl macrolides having immunosuppressive activity

1992-08-04

1993-09-21

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D49816, A61K 31395

Patent

active

052470768

ABSTRACT:
Imidazolidyl macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.

REFERENCES:
patent: 5064835 (1991-11-01), Bochis et al.
patent: 5110811 (1992-05-01), Okuhara et al.
patent: 5118677 (1992-06-01), Caufield
patent: 5118678 (1992-06-01), Kao et al.
Barton, et al., J. Chem. Soc., Chem. Commun., 65-66 (1986) (I).
Barton, et al., Tetrahedron Lett., 27(31), 3615-3618 (1986) (I).

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