Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1983-05-25
1984-08-07
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
546 15, 548309, 424256, 424273R, A61K 31435, C07D40114
Patent
active
044643802
ABSTRACT:
A series of novel spiro-oxindole imidazolidinedione derivatives have been prepared, including their pharmaceutically acceptable salts. These compounds are useful in therapy as aldose reductose inhibitors for the control of certain chronic diabetic complications. Preferred compounds include 6'-amino-spiro-[imidazolidine-4,3'-indoline]-2,2',5-trione, 5'-chloro-7'-amino-spiro-[imidazolidine-4,3'-indoline]-2,2',5-trione, 1'-(3-pyridylmethyl)-5'-fluoro-spiro-[imidazolidine-4,3'-indoline]-2,2',5- trione, 1'-(3-pyridylmethyl)-5',7'-dichloro-spiro-[imidazolidine-4,3'-indoline]-2, 2',5-trione and spiro-[imidazolidine-4,3'-(6-azaindoline)]-2,2',5-trione. Methods for preparing these compounds from known starting materials are provided.
REFERENCES:
patent: 3821383 (1974-06-01), Sestanj et al.
patent: 4200642 (1980-04-01), Schnur
H. Otomasu et al., "Spiro Heterocyclic Compounds. I. Synthesis of Spiro-[imidazoline-4,3'-indoline]-2,2',5-triones", Chem. Pharm., Bull., (Tokyo), vol. 23, No. 7, p. 1431, (1975).
Bond Robert T.
Knuth Charles J.
Pfizer Inc.
Richardson Peter C.
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