Imidazolidine carboxamide derivatives as P2X7 modulators

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S322500

Reexamination Certificate

active

07932282

ABSTRACT:
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof:The compounds or salts modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor (P2X7 receptor antagonists). The invention also provides the use of such compounds or salts, or pharmaceutical compositions thereof, in the treatment or prevention of disorders/diseases mediated by the P2X7 receptor, for example pain, inflammation or a neurodegenerative disease, in particular pain such as inflammatory pain, neuropathic pain or visceral pain.

REFERENCES:
patent: 2005/0026916 (2005-02-01), Shum et al.
patent: 2008/0009541 (2008-01-01), Chambers et al.
patent: 5024287 (1975-03-01), None
patent: WO 99/29686 (1999-06-01), None
patent: WO 01/10799 (2001-02-01), None
patent: WO 2008/003697 (2008-01-01), None

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