Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-10-31
1988-01-12
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514398, 548317, 548321, 548337, A61K 31415, C07D23342
Patent
active
047192232
ABSTRACT:
Potent dopamine-.beta.-hydroxylase inhibitors having the Formula: ##STR1## which are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in mammals. Also disclosed are novel intermediates useful in preparing the presently invented inhibitors.
REFERENCES:
patent: 2180772 (1939-11-01), Scherer
patent: 3488423 (1970-01-01), Doebel et al.
patent: 3915980 (1975-10-01), Gebert et al.
patent: 4340738 (1982-07-01), Sipido
patent: 4487761 (1984-12-01), Cole et al.
patent: 4532331 (1985-07-01), Frazee et al.
J. Topliss, J. Med. Chem., 1972, 15(10), 1006-1010.
P. Iverson, et al., Acta Cem. Scand., 21:279-285, (1967).
R. Fuller, et al., Adv. Enzyme Regul., 15:267-281, (1976).
C. Runti, et al., Il. Farmaco Ed. Sc., 36:260-268, (1980).
Goldstein, Pharmacol. Rev., 18:77-82, (1966).
V. Gebert, et al., Chemical Abstracts, 72:39275e, (1970), [Z. Physiol. Chem., 1969, 350(11), 1327-30].
H. Hidaka, et al., Mol. Pharmacol., 9:172-177, (1973).
Kaiser Carl
Kruse Lawrence I.
Ross Stephen T.
Fabiano Vincent L.
Lourie Alan D.
Schwartz Richard A.
SmithKline Beckman Corporation
Suter Stuart R.
LandOfFree
Imidazolethiol dopamine-beta-hydroxylase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Imidazolethiol dopamine-beta-hydroxylase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazolethiol dopamine-beta-hydroxylase inhibitors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-921385