Imidazoles with serotonin receptor binding activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 314174, A61P 2506

Patent

active

061243388

ABSTRACT:
This invention relates compounds having serotonin receptor binding activity, to pharmaceutical compositions containing them and to their medical use, particularly in the treatment of CNS conditions. Described herein are compounds which have the general formula: ##STR1## wherein R.sup.1 is selected from H, C.sub.1-6 alkyl and benzyl;

REFERENCES:
patent: 4602093 (1986-07-01), Baldwin et al.
patent: 5312927 (1994-05-01), Takada et al.
Drost et al. Can. Soc. Forens. Sci. J. vol. 22. No. 4 (1989) "A Possible Imidazole Metabolite of Xylometazoline in Human Postmortem Liver".
Slavica et al. J. Med. Chem. 1994, 37, 1874-1881 "Synthesis and Biological Activities of a New Set of Irreversibly Acting 2-(4'-Isothiocynatobenzyl) Imidazoline Analogs in Rat Thoracic Aorta".
Miller et al. J. Med. Chem. 1990, 33, 1138-1144 "Synthesis and .alpha..sub.2 -Adrenoceptor Effects of Substituted Catecholimidazoline and Catecholimidazole Analogues in Human Platelets".
Wahhab et al. Arzneim.-Forsch./Drug Res. 43 (II), Nr. 11 (1993), 1157-1168 "Imidazole Based Non-Peptide Angiotensin II Receptor Antagonists".
Baldwin et al. J. Med. Chem. 1986, 29, 1065-1080 ".beta..sub.1 -Selective Adrenoceptor Antagonists: Examples of the 2-[4-[3-(Substituted amino)-2- hydroxypropoxyl[phenyl]imidazole Class. 2".
Savola et al. Arzneim.-Forsch./Drug Res. 38 (I), Nr. 1 (1988), 29-35 "Cardiovascular and Sedative .alpha.- Adrenoceptor Effects of Detomidine-like Arlalkyl Imidazoles and Associated Derivatives".
Iwasaki Helvetica Chimica Acta--vol. 59, Fasc. 8 (1976)--Nr. 294, 2738-2752 "Photochemistry of Imidazolides. I. The Photo-Fries-Type Rearrangement of N-Substituted Imidazoles".
Maeda, CA 109:13649 (1988), "Imidazole Derivatives Volatile Corrosion, etc. "
Naylor et al., CA 120:244974(1994) "Heterocyclic Mono-N-Oxides, etc."
Hirao et al., CA 124:94708(1995) "Aralkylimidazole Containing, etc."

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Imidazoles with serotonin receptor binding activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imidazoles with serotonin receptor binding activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazoles with serotonin receptor binding activity will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2100676

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.