Imidazole with angiotensin II antagonist properties

Details Imidazole with angiotensin II antagonist properties Imidazole with angiotensin II antagonist properties

1992-12-04

1994-06-21

Morris, Patricia L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548252, 548254, 5483121, C07D40314, C07D40306

Patent

active

053229509

ABSTRACT:
This invention relates to novel substituted imidazole and triazole derivatives which antagonize the binding of angiotensin II to its receptors. The compounds are useful in the treatment of hypertension, heart failure, glaucoma, and hyperaldosteronism. Methods of making the compounds, novel intermediates useful in the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of using them are also covered.

REFERENCES:
patent: 4355040 (1982-10-01), Furukawa et al.
patent: 4820843 (1989-04-01), Aldrich
patent: 5128355 (1992-07-01), Carini et al.
patent: 5138069 (1992-08-01), Carini et al.

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