Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-10-04
1994-12-20
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514947, A61K 31495, A61K 3150
Patent
active
053746333
ABSTRACT:
Topically administerable compositions are described which contain, in a pharmaceutically acceptable vehicle, a combination of a drug whose dermal penetration can be enhanced and a combination of substances, which combination enhances and controls the penetration of the compositions through the skin. The combination contains an antifungal amount of an imidazole and a certain amount of either propylene glycol, specified fatty acid ester(s) or a mixture of propylene glycol and specified fatty acid ester(s).
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S. Bennett, et al., "Optimization of Bioavailability of Topical Steroids: Non-occluded Penetration Enhancers under Thermodynamic Control", J. Pharm. Pharmacol. 1985, 37:298-304.
Bristol--Myers Squibb Company
Hollinden Gary E.
Nolan Sandra
Santini Anthony M.
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