Imidazole derivatives, process for their preparation and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S290000, C514S387000, C514S397000, C544S234000, C546S101000, C548S302100, C548S311400, C548S311700, C548S304400

Reexamination Certificate

active

06960586

ABSTRACT:
The present invention provides a compound having a steroid C17,20-lyase inhibitory activity, which is useful as a prophylactic or therapeutic agent of prostatism and tumor such as breast cancer and the like.A compound represented by the formula:wherein R is a hydrogen atom or a protecting group, R1is a lower alkyl group or a cyclic alkyl group, and ring A and ring B are each an optionally substituted 5-membered or 6-membered ring having an amide bond in the ring, or a salt thereof.

REFERENCES:
patent: 5491161 (1996-02-01), Janssen et al.
patent: 0260744 (1988-03-01), None
patent: 0288053 (1988-10-01), None
patent: 0413270 (1991-02-01), None
patent: 0721943 (1996-07-01), None
patent: 0974584 (2000-01-01), None
patent: 1028110 (2000-08-01), None
patent: WO 92/15404 (1992-09-01), None
patent: WO 92/15604 (1992-09-01), None
patent: WO 94/27989 (1994-12-01), None
patent: WO 96/14090 (1996-05-01), None
patent: WO 97/00257 (1997-01-01), None
patent: WO 93/20097 (1998-10-01), None
patent: WO 99/54309 (1999-10-01), None
Njar and Brodie, “Inhibitors of 17alpha-Hydroxylase/17,20-Lyase (CYP17): Potential Agents for the Treatment of Prostate Cancer” Current Pharmaceutical Design, vol. 5, pp. 163-180 (1990).
Beckmann et al. “Multistep carcinogenesis of breast cancer and tumour heterogeneity” Journal of Molecular Medicine, vol. 75(6 pp. 429-439 (1997).
Al-Dabbagh and Smith, “Species differences in oxidative drug metabolism: some basic considerations.” Archives of toxicology. Supplement. Archiv fur Toxikologie. supplement, vol. 7, pp. 219-231 (1984).
Hans Bundgaard, Design of Prodrugs, p. 1. © 1985 Elsevier Science Publishers.
Richard B. Silverman, The Organic Chemistry of Drug Design and Drug Action, pp. 352-400. © 1992 Academic Press, Inc.
Ingvarsson, “Molecular genetics of breast cancer progression” Seminars in Cancer Biology, vol. 9, pp. 277-288 (1999).
Wachall, et al. “Imidazole Substituted Biphenyls: A New Class of Highly Potent and In Vivo Active Inhibitors of P450 17 as Potential Therapeutics for Treatment of Prostate Cancer” Bioorganic & Medicinal Chemistry 7:1913-1924 (1999).
Zhuang, et al. “Novel Imidazolyl and Triazolyl Substituted Biphenyl Compounds: Synthesis and Evaluation as Nonsteroidal Inhibitors of Human 17 α-Hydroxylase-C17, 20-Lyase (P450 17)” Bioorganic & Medicinal Chemistry 8: 1245-1252 (2000).

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