Imidazole derivatives having therapeutical activity, process for

Details Imidazole derivatives having therapeutical activity, process for Imidazole derivatives having therapeutical activity, process for

1990-11-16

1992-04-14

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548341, C07D23356, A61K 31415

Patent

active

051048930

ABSTRACT:
The econazole and miconazole sulfosolicylic acid addition salts show, in vitro, a relevant anti-fungal activity with wide spectrum and, if locally applied, are well tolerated and more effective than the corresponding nitrates for the control, in vivo and clinically, of the mycosis as induced from dermatophytes and from Candida albicans.

REFERENCES:
patent: 4657923 (1987-04-01), DiSchiena
Merck Index, Eighth Ed., Merck and Co., Rahway, N.J., 1968, pp. 1003-1004.
Chemical Abstracts, 103:193006h (1985) [Khadikar, P. et al., Indian J. Pharm. Sci. 1984, 46(6), 209-211].
Chemical Abstracts, 106:192587y (1987) [Khadikar, P. et al., Rev. Microbiol. 1986, 17(4), 291-295].

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