Imidazole derivatives having anti-HIV activity

Details Imidazole derivatives having anti-HIV activity Imidazole derivatives having anti-HIV activity

1994-03-14

1995-12-05

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514341, 514269, 514256, 514397, 514376, 514374, 514377, 514365, 514369, 514370, 546278, 544333, 544315, 544316, 544317, 544318, 544238, 544405, 5483144, 5483127, 548233, 548235, 548182, 548183, 548184, 548186, 548189, 548190, 548193, 548198, 548203, 548205, A01N 4354, A01N 4350, A01N 4358, A01N 4360, C07D40112, C07D40312, C07D40306, C07D40106

Patent

active

054729653

ABSTRACT:
A novel imidazole derivatives of formula I: ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, or optionally substituted aryl; R.sup.2 is alkyl, optionally substituted aryl optionally substituted aralkyl, or optionally substituted hetero ring group; R.sup.3 is hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl, or optionally substituted hydroxyalkyl; R.sup.4 is hydrogen, alkyl, halogen, acyl, optionally substituted hydroxyalkyl, optionally esterified or amidated carboxyl group, hydroxy group, aryl or arylthio; X is S, SO, SO.sub.2, CH.sub.2, or Se; n is an integer of 1 to 3, or a pharmaceutically acceptable salt thereof, said derivative having anti-HIV activity and being useful for the treatment of HIV infections.

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Iddon et al., J. Chem. Soc. Perkin Trans. 1, No. 4 (1983) pp. 735-738.
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Iddon et al., J. Chem. Soc. Chem. Commun. No. 21 (1981) pp. 1095-1097: Chemical Abstracts, vol. 96 (1982) p. 750 No. 142762f.
Kaneko et al., Chem. Pharm. Bull. vol. 39 No. 4 (1991) pp. 871-875.
Chemical Abstracts, vol. 115 (1991) p. 988 No. 159603p.
McGee et al., Nucleosides and Nucleotides 9(6) 1990 pp. 815-826.
Alonso et al., J. Med. Chem., vol. 28 No. 6 (1985) pp. 834-838.

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