Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1981-02-09
1983-09-20
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548335, A61K 31415
Patent
active
044056346
ABSTRACT:
1-Substituted-imidazoles of the formula: ##STR1## in which A is selected from the group consisting of straight or branched, saturated or unsaturated, acyclic hydrocarbon radicals of from 1 to 3 carbon atoms and R is ##STR2## wherein n is an integer which is at least 1, and the or each Q substituent, which when n is greater than 1 may be the same or different, is selected from a saturated alkyl group of from 1 to 4 carbon atoms or an unsaturated alkyl group of from 2 to 4 carbon atoms, with the proviso that when A is unsaturated Q may also be selected from alkoxy of from 1 to 4 carbon atoms; halo; trihalomethyl; hydroxy; carboxyl; a salt of such a carboxyl group; carboalkyloxy; carboaryloxy; carboarylalkyloxy; --NR.sup.6 R.sup.7 or --CONR.sup.6 R.sup.7 ; in which R.sup.6 and R.sup.7 may be the same or different and are hydrogen or alkyl of from 1 to 4 carbon atoms; the 1-substituted-imidazole being the free base or an acid addition salt thereof.
Methods of preparing the 1-substituted-imidazoles are also provided.
The imidazoles have pharmacological properties that make them of use in the treatment of thromboembolic disorders, shock and angina pectoris.
REFERENCES:
patent: 4226878 (1980-10-01), Iizuka et al.
Tai, H. et al., Biochem. Biophys. Res. Comm., 80(1), 236-242 (1978).
Moncada, S. et al., Prostaglandins, 13(4), 611-618 (1977).
Gove, P. (editor), Webster's Third New International Dictionary, G. and C. Merriam Co., Springfield, Mass., 1963, p. 1157.
Brown Donald
Burroughs Wellcome Co.
Schwartz Richard A.
LandOfFree
Imidazole derivatives for treating myocardial infarction does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Imidazole derivatives for treating myocardial infarction, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazole derivatives for treating myocardial infarction will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-587949