Imidazole derivatives as therapeutic agents

Details Imidazole derivatives as therapeutic agents Imidazole derivatives as therapeutic agents

1997-01-23

1998-07-14

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514397, 5483361, 5483421, C07D23361, C07D23364, A61K 31415

Patent

active

057806420

ABSTRACT:
Compounds of the formula I ##STR1## and pharmaceutically acceptable salts thereof in which R.sub.1 represents hydrogen, halo, cyano, cyanoalkyl, alkyl, alkoxy, phenoxy, phenyl, alkoxycarbonyl, --NR.sub.13 R.sub.14, --N(R.sub.15)SO.sub.2 R16, halogenated alkoxy, halogenated alkyl, arylalkoxy, hydroxy, phenylalkyl, alkoxycarbonylvinyl, --S(O).sub.n R.sub.7, alkoxycarbonylalkyl, carboxyalkyl, --CONR.sub.11 R.sub.12 carbamoylvinyl, --OSO.sub.2 R.sub.21, 4,5-dihydrothiazol-2-yl, 4,4-dimethyl-2-oxazolin-2-yl or --NR.sub.60 R.sub.61 ; or R.sub.1 represents a group of formula --(O).sub.z --L.sub.3 G wherein z equals 0 or 1, L.sub.3 represents a C.sub.1-4 alkylene chain, G represents a group of formula a), b), c), or d): a) --NR.sub.22 R.sub.23 ; b) --S(O).sub.m R.sub.26 ; c) CONR.sub.27 R.sub.28 ; d) --OR.sub.29 ; R.sub.2 and R.sub.3 independently represent hydrogen, halo, alkyl, alkoxy, --NR.sub.13 R.sub.14, halogenated alkoxy, halogenated alkyl, hydroxy, --S(O).sub.n R.sub.7 or --NR.sub.60 R.sub.61 ; L.sub.1 represents e) a bond, or f) alkylene, cycloalkylene or cycloalkylidene; T represents a bond or O, S, SO, SO.sub.2, a carbonyl group, or 1,3-dioxolan-2-ylidene; L.sub.2 represents alkylene, cycloalkylene, or cycloalkylidene; R.sub.6 represents hydrogen or alkyl (optionally substituted by alkoxycarbonyl or hydroxy); Q represents a C.sub.1-9 alkylene chain (optionally substituted by alkyl or hydroxy); and Y represents an optionally substituted imidazole ring; which are antiinflammatory, antiallergic and immunodulant agents. Compositions containing these compounds and processes to make them are also disclosed.

REFERENCES:
patent: 3821241 (1974-06-01), Schmidt et al.
patent: 4226878 (1980-10-01), Iizuka et al.
patent: 4338453 (1982-07-01), Gall
patent: 4378361 (1983-03-01), Schromm et al.
patent: 4404387 (1983-09-01), Gall
patent: 4581370 (1986-04-01), Diamond et al.
patent: 4599427 (1986-07-01), Oeckl et al.
Ferroni et al., Il Farmaco, 44(5), 495-502 (1989).
Sadanandam et al., Ind. J. Pharmac., 5(4), 428-441 (1973).
Sadanandam et al., Pfl. Krankh., Mar. 1975, 149-161 (1975).
Traylor et al., J. Am. Chem. Soc., 101:18, 5376-5383 (1979).
Luts et al., J. Pharm. Sciences, 61, 1504-1506 (1972).
Godefroi et al., J. Med. Chem., 12, 784-791 (1969).
Sidhu et al., Arch. Pharmaz., 306, 310-319 (1973).
Stark et al., Eur. J. Med. Chem., 26, 645-700 (1994).

Affiliated with

Also associated with

Rating

Imidazole derivatives as therapeutic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imidazole derivatives as therapeutic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazole derivatives as therapeutic agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1883126