Imidazole derivatives as protective agents in reperfusion injury

Details Imidazole derivatives as protective agents in reperfusion injury Imidazole derivatives as protective agents in reperfusion injury

1994-05-20

1996-06-11

Haley, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514397, 5483127, 5483021, C07D 4936

Patent

active

055256210

ABSTRACT:
Compounds of the formula ##STR1## wherein the substituents are as defined in the disclosure. The compounds are particularly useful for inhibiting damage to a variety of mammalian tissue that are jeopardized, for example, during runaway inflammatory conditions due to the damaging presence of singlet oxygen, the hydroxyl radical, cytokines and growth factors. The compounds are also useful in inhibiting damage to cardiac and central nervous system tissues during reperfusion.

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