Imidazole derivatives as phosphodiesterase VII inhibitors

Details Imidazole derivatives as phosphodiesterase VII inhibitors Imidazole derivatives as phosphodiesterase VII inhibitors

2004-01-05

2009-02-17

Hui, San-ming (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

Reexamination Certificate

active

07491742

ABSTRACT:
Imidazole derivatives of the formula Iin whichR1is H, A, benzyl, indan-5-yl, 1,2,3,4-tetrahydronaphthalen-5-yl, dibenzothien-2-yl, or phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal, A, A-CO—NH, benzyloxy, alkoxy, COOH or COOA,R2is H or A,X is O or S,Hal is F, Cl, Br or I,A is alkyl with 1 to 6 C atoms,and the physiologically acceptable salts and/or solvates thereof as phosphodiesterase VII inhibitors and the use thereof for producing a pharmaceutical.

REFERENCES:
Carter et al., Chemotherapy of Cancer 2nd ed 1981.
Christodoulos et al., Chest. 1999; 115(5): 1471.
The abstract of Savel'ev et al. Khimiko-Farmatsevticheskii Zhurnal, 1993; 17(6):697-700.
Hungarian Search Report for application P0203139, dated Nov. 5, 2004.
Abstract of HU Pub. No. 58337, published Feb. 28, 1992, of App. No. HU P 89 04659 A, assigned to The Boots Co. Plc.

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