Imidazole derivatives as inhibitors of TXA.sub.2 synthesis

Details Imidazole derivatives as inhibitors of TXA.sub.2 synthesis Imidazole derivatives as inhibitors of TXA.sub.2 synthesis

1986-01-14

1990-01-16

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142278, 5142358, 514252, 514256, 514318, 514326, 514333, 514340, 514341, 514365, 514383, 514399, 544 585, 544 586, 544 587, 544120, 544122, 544131, 544132, 544133, 544139, 544295, 544296, 544333, 544357, 544364, 544369, 544370, 544405, 546194, 546209, 546210, 546256, 546276, 546278, 548146, 548204, 548262, 548336, 548341, A61K 31415, C07D40506, C07D40906

Patent

active

048943851

ABSTRACT:
Compounds of formula (I): ##STR1## (wherein n is 0, 1 or 2 and R.sup.1, R.sup.2, R.sup.4, R.sup.5, R.sup.6, X, Y and Z are a variety of groups and atoms) have the ability to inhibit the synthesis of thromboxane A.sub.2 and hence are useful in the treatment or prophylaxis of thrombotic conditions.

REFERENCES:
patent: 4632934 (1986-12-01), Iizuka et al.

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