Imidazole derivatives as 5-HT.sub.3 receptor antagonists

Details Imidazole derivatives as 5-HT.sub.3 receptor antagonists Imidazole derivatives as 5-HT.sub.3 receptor antagonists

1988-09-30

1990-04-17

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514397, 514400, 546112, 546183, 548336, 548342, A61K 3144, A61K 31415, C07D40306, C07D47104

Patent

active

049180797

ABSTRACT:
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein the various substituents are defined hereinbelow, having 5-HT.sub.3 receptor antagonist activity, processes for their preparation and their use as pharmaceuticals.

REFERENCES:
patent: 4622336 (1986-11-01), Achini
patent: 4720551 (1988-01-01), Fujita et al.
patent: 4772613 (1988-09-01), Parsons et al.
patent: 4808581 (1989-02-01), Oxford et al.
patent: 4814344 (1989-03-01), Humber et al.
J. Fozard in The Peripheral Actions of 5-Hydroxy-Tryptamine, (J. Fozard, Editor), Oxford Univ. Press, Oxford, 1989, pp. 354-376.
Ch. Ab. 109:104602h, 1988, Scheinen et al.
Ch. Abs. 108(17):150475, 1988, Karjalainen et al.

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