Imidazole derivatives and salts thereof

Details Imidazole derivatives and salts thereof Imidazole derivatives and salts thereof

1979-08-17

1983-08-02

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424273R, 542457, 542458, 542470, 548341, C07D23358, C07D23360

Patent

active

043967710

ABSTRACT:
1-Substituted-imidazoles of the formula: ##STR1## in which A is selected from the group consisting of straight or branched, saturated or unsaturated, acyclic hydrocarbon radicals of from 1 to 3 carbon atoms and R is ##STR2## wherein n is an integer which is at least 1, and the or each Q substituent, which when n is greater than 1 may be the same or different, is selected from a saturated alkyl group of from 1 to 4 carbon atoms or an unsaturated alkyl group of from 2 to 4 carbon atoms, with the proviso that when A is unsaturated Q may also be selected from alkoxy of from 1 to 4 carbon atoms; halo; trihalomethyl; hydroxy; carboxyl; a salt of such a carboxyl group; carboalkyloxy; carboaryloxy; carboarylalkyloxy; --NR.sup.6 R.sup.7 or --CONR.sup.6 R.sup.7 ; in which R.sup.6 and R.sup.7 may be the same or different and are hydrogen or alkyl of from 1 to 4 carbon atoms; the 1-substituted-imidazole being the free base or an acid addition salt thereof.
Methods of preparing the 1-substituted-imidazoles are also provided.
The imidazoles have pharmacological properties that make them of use in the treatment of thromboembolic disorders, shock and angina pectoris.

REFERENCES:
patent: 3853995 (1974-12-01), Wehrmeister
patent: 3927017 (1975-12-01), Heeres et al.
patent: 4006243 (1977-02-01), Strehlke et al.
patent: 4036975 (1977-07-01), Walker et al.
patent: 4085209 (1978-04-01), Miller et al.
patent: 4110447 (1978-08-01), Gante et al.
patent: 4115578 (1978-09-01), Miller et al.
Iwasaki, S., Helv. Chim. Acta, 59(8), 2753-2764, (1976).
Iwasaki, S., Helv. Chim. Acta, 61(8), 2831-2842, (1978).
Moncada, S. et al., Prostaglandins, 13(4), 611-618, (1977).
Baggaley, K. et al., J. Med. Chem., 18(8), 833-836, (1975).

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