Imidazole derivatives and process for preparing the same

Details Imidazole derivatives and process for preparing the same Imidazole derivatives and process for preparing the same

1999-05-19

2000-08-15

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514400, 5483381, 5483415, A61K 31415, C07D23360, C07D23361

Patent

active

061037478

ABSTRACT:
The invention relates to the imidazole derivatives as selective antagonistic substances against muscarinic acetylcholine and provides imidazole derivatives represented by a general formula (1) or (2) ##STR1## [wherein R.sub.1 is a phenyl group which may have substituent or thienyl group, R.sub.2 is a cyano group, a carboxyl group, CONR.sub.7 R.sub.8 group (wherein R.sub.7 and R.sub.8 each independently represent hydrogen atom or lower alkyl group, or R.sub.7 and R.sub.8 may form a ring by alkylene chain which may contain hetero atom) or COOR.sub.9 group (wherein R.sub.9 is a lower alkyl group), R.sub.3 is a hydrogen atom or lower alkyl group, R.sub.4, R.sub.5 and R.sub.6 each independently represent hydrogen atom, lower alkyl group which may have substituent or cycloalkyl groups, or may form a condensed ring at the positions of R.sub.5 and R.sub.6 with benzene ring, R.sub.10 is a lower alkyl group or an aralkyl group which may have substituent, m is an integer from 1 to 6, and z is a halogen atom].

REFERENCES:
patent: 4073921 (1978-02-01), Miller et al.
patent: 4225723 (1980-09-01), Miller et al.
patent: 4320134 (1982-03-01), Iizuka et al.
patent: 4605661 (1986-08-01), Hirsch et al.
patent: 4923865 (1990-05-01), Cossement et al.
Carl Kaiser et al., "Synthesis and Antimuscarinic Properties of Some N-Substituted 5-(Aminomethyl)-3,3-Diphenyl-2(3H)-Furanones", J. Med. Chem., vol. 35, pp. 4415-4424, 1992.
Donald J. Cram et al., "Organic Chemistry", McGraw-Hill Book Company, 2.sup.nd Edition, pp. 565-567, 1964.

Affiliated with

Also associated with

Rating

Imidazole derivatives and process for preparing the same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imidazole derivatives and process for preparing the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazole derivatives and process for preparing the same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2007317