Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1979-08-21
1986-12-30
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548341, C07D23354, A61K 31415
Patent
active
046329340
ABSTRACT:
The imidazole derivatives of the formula: ##STR1## wherein R is a hydrogen atom or an alkyl group, A.sub.1 and A.sub.2, which may be the same or different, each is an alkylene or an alkylene group, m is 0 or 1, and Z is ##STR2## wherein R.sub.1 and R.sub.2, which may be the same or different, each is a hydrogen atom or an alkyl group, and the terminal carbon atom bonded to the hetero atom of Z may be bonded to either A.sub.1 or A.sub.2 or COOR group (in the case of m being 0); and the pharmaceutically acceptable salts thereof. These compounds have a strong inhibitory effect on thromboxane synthetase from human or bovine platelet microsomes, and are useful as therapeutically actives for inflammation, hypertension, thrombus, cerebral apoplexy and asthma.
REFERENCES:
patent: 4017631 (1977-04-01), Janssen et al.
patent: 4101665 (1978-07-01), Heeres
Ajisawa Yukiyoshi
Akahane Keniji
Iizuka Kinji
Kamijo Yukio
Momose Den-ichi
Jiles Henry R.
Kissei Pharmaceutical Co. Ltd.
Ono Pharmaceutical Co. Ltd.
Whittenbaugh Robert C.
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