Imidazole derivatives and antimycotics containing them

Details Imidazole derivatives and antimycotics containing them Imidazole derivatives and antimycotics containing them

1987-12-23

1990-05-15

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548341, 548336, 546276, 514399, 514397, A61K 31415, C07D23354, C07D40300, C07D40100

Patent

active

049258559

ABSTRACT:
New imidazole derivatives of the formula ##STR1## in which Ar denotes phenyl, biphenylyl, naphthyl or thienyl, each of which is optionally substituted by halogen, lower alkyl or lower alkoxy, R.sub.1 denotes hydrogen or lower alkyl, Alk denotes straight-chain or branched alkylene having 1 to 10 carbon atoms, Y denotes oxygen, sulfur, sulfinyl or sulfonyl, n denotes one of the numbers 0, 1 or 2, Z denotes sulfur or sulfinyl, m denotes the number 0 or 1, m being the number 0 when Y denotes sulfur, sulfinyl or sulfonyl, and m being the number 1 when Y denotes oxygen, and R.sub.2 denotes cyclohexyl, phenyl or naphthyl, each of which is optionally substituted by hydroxyl, halogen, trifluoromethyl, lower alkyl or lower alkoxy, or denotes biphenylyl or pyridyl, and processes for their preparation. The imidazole derivatives have excellent antimycotic properties for use in human and veterinary medicine.

REFERENCES:
patent: 3839574 (1974-10-01), Godefroi et al.
patent: 4559077 (1985-12-01), Regel et al.
patent: 4568687 (1986-02-01), Wright, Jr. et al.
patent: 4623655 (1986-11-01), Gayer et al.
H. Buchel, "The History of Azole Chemistry," 1986, pp. 11-23.
G. Jager, "The Chemistry of N-Substituted Azole Fungicides, "1983, pp. 55-65.
Godefroi et al., J. Med. Chem. 1969, pp. 784-791.

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