Imidazole derivatives and angina pectoris

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

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542457, 542458, 542468, 542470, 548335, A61K 31415

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active

043573401

ABSTRACT:
1-Substituted-imidazoles of the formula: ##STR1## in which A is selected from the group consisting of straight or branched, saturated or unsaturated, acyclic hydrocarbon radicals of from 1 to 3 carbon atoms and R is ##STR2## wherein n is an integer which is at least 1, and the or each Q substituent, which when n is greater than 1 may be the same or different, is selected from a saturated alkyl group of from 1 to 4 carbon atoms or an unsaturated alkyl group of from 2 to 4 carbon atoms, with the proviso that when A is unsaturated Q may also be selected from alkoxy of from 1 to 4 carbon atoms; halo; trihalomethyl; hydroxy; carboxyl; a salt of such a carboxyl group; carboalkyloxy; carboaryloxy; carboarylalkyloxy; --NR.sup.6 R.sup.7 or --CONR.sup.6 R.sup.7 ; in which R.sup.6 and R.sup.7 may be the same or different and are hydrogen or alkyl of from 1 to 4 carbon atoms; the 1-substituted-imidazole being the free base or an acid addition salt thereof.
Methods of preparing the 1-substituted-imidazoles are also provided.
The imidazoles have pharmacological properties that make them of use in the treatment of thromboembolic disorders, shock and angina pectoris.

REFERENCES:
patent: 4085209 (1978-04-01), Miller et al.
patent: 4110447 (1978-08-01), Gante et al.
patent: 4115578 (1978-09-01), Miller et al.
patent: 4226878 (1980-10-01), Iizuka et al.
Baggaley, K., et al., J. Med. Chem., 18(8), 833-836 (1975).

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