Imidazole derivatives

Details Imidazole derivatives Imidazole derivatives

2006-08-15

2006-08-15

Morris, Patricia L. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S272700, C546S272400, C546S274700, C546S275100

Reexamination Certificate

active

07091222

ABSTRACT:
The present invention relates to imidazole derivatives of the general formulawherein R1, R2, R3and R4are as defined hereinabove. This invention also relates to the compound's pharmaceutically acceptable salt and processes for the preparation thereof. These compounds can be used for the manufacture of pharmaceutical compositions for the treatment and prevention of mGluR5 receptor mediated disorders. These compounds are useful, inter alia, in the treatment or prevention of acute and/or chronic neurological disorders such as psychosis, epilepsy, schizophrenia, Alzheimer's disease, cognitive disorders and memory deficit disorders, as well as chronic and acute pain.

REFERENCES:
patent: 2005/0143375 (2005-06-01), Buettelmann et al.
patent: 0 304 910 (1989-03-01), None
Arena F. et al, Journal of Medicinal Chemistry, American Chemical Society, XP001005697, vol. 18, No. 11, pp. 1147-1150 (1975).
Sonogashira et al., Synthesis, pp. 777-778 (1977).
Cliff et al., Synthesis, 681, pp. 681-682 (1994).
Schlaeger et al., Cytotechnology, 30, pp. 71-83 (1999).
Porter et al., Br. J. Pharmacol., 128, pp. 13-20 (1999).

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