Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-07-05
2011-07-05
Morris, Patricia L (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C546S256000, C546S275100, C544S333000, C544S405000
Reexamination Certificate
active
07973165
ABSTRACT:
The present invention relates to process for the preparation of an imidazole derivative of formula I,wherein R1, R2, R3and R4are described hereinabove. These compounds can be used in the treatment or prevention of mGluR5 receptor mediated disorders. These compounds are useful, inter alia, in the treatment or prevention of acute and/or chronic neurological disorders such as psychosis, epilepsy, schizophrenia, Alzheimer' disease, cognitive disorders and memory deficits, as well as chronic and acute pain.
REFERENCES:
patent: 4508560 (1985-04-01), Brunner et al.
patent: 7091222 (2006-08-01), Buettelmann et al.
patent: 7153874 (2006-12-01), Buettelmann et al.
patent: 2004/0259917 (2004-12-01), Cosford et al.
patent: WO 99/02497 (1999-01-01), None
patent: WO 01/16121 (2001-03-01), None
patent: WO 02/08205 (2002-01-01), None
patent: WO 02/46166 (2002-06-01), None
patent: 2004/038374 (2004-05-01), None
Dorwald , Side Reactions in Organic Synthesis, 2005, Wiley: VCH Weinheim Preface, pp. 1-15 & Chapter 8, pp. 279-308.
Kiyomori et al., An Efficient Copper-Catalyzed Coupling of Aryl Halides with Imidazoles, Tetrahedron Letters (1999), 40, 2657-2660.
Cliff et al., Synthesis of 4,4′-Biimidazoles, Synthesis (1994), 681-682.
Collman et al., An Efficient Diamine Copper Complex-Catalyzed Coupling of Arylboronic Acids with Imidazoles, Organic Letters (2000), 2(9), 1233-1236.
Ohira, S., Methanolysis of Dimethyl(1-diazo-2-oxopropyl)phosphonate and Reaction with Carbonyl Compounds, Synthetic Communications (1989), 19 (3&4), 561-564.
Tohda et al., A Convenient Synthesis of 1-Alkynyl Ketones and 2-alkynamides, Synthesis (1977), 777-788.
Gasparini et al., 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a Potent, Selective and Systemically Active mGlu5 Receptor Antagonist, Neuropharmacology (1999), 38, 1493-1503.
Spooren et al., Novel Allostericant Agonists Shed Light on mGlu5 Receptors and CNS Disorders, Trends in Pharmacological Sciences (2001), 22(7): 331-337.
Buettelmann Bernd
Ceccarelli Simona Maria
Jaeschke Georg
Kolczewski Sabine
Porter Richard Hugh Philip
Hoffmann-La Roche Inc.
Johnston George W.
Morris Patricia L
Prior Kimberly J.
Rocha-Tramaloni Patricia S.
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