Imidazole derivative and medicine comprising the same as active

Details Imidazole derivative and medicine comprising the same as active Imidazole derivative and medicine comprising the same as active

1998-11-30

2000-06-06

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483415, 5483361, A01N 4350, C07D23364, C07D23370

Patent

active

060719435

ABSTRACT:
Disclosed herein are an imidazole derivative represented by the following general formula (1): ##STR1## wherein R.sup.1 is a hydrogen atom, or an alkyl, alkoxy or alkoxycarbonyl group, and R.sup.2, R.sup.3 and R.sup.4 are the same or different from one another and are independently a hydrogen or halogen atom, an alkyl, halogenoalkyl, hydroxyl or alkoxy group, or the like, or a salt thereof, and a medicine comprising such a compound. The compound specifically suppresses the production of particular cytokine and is hence useful as an active ingredient for immune function modulators and the like.

REFERENCES:
Oganesyan et al., Electronic structure activity relationships for propenone derivatives, Khim.--Farm. Zh., 29(10), pp. 28-30, Dec. 1995.
D.G. Batt, et al., Journal of Medicinal Chemistry, vol. 36, No. 10, pps. 1434-1442, "2'-Substituted Chalcone Derivatives as Inhibitors of Interleukin-1 Biosynthesis", 1993.

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