Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1979-06-13
1980-10-07
Randolph, John D.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548335, C07D23360, A61K 31415
Patent
active
042268788
ABSTRACT:
Novel imidazole derivatives of the general formula (I): ##STR1## wherein Y is a carboxyl group, an alkoxycarbonyl group, a cyano group, a hydroxymethyl group, an aminomethyl group, a formyl group or a carbamoyl group, and A and B, which may be the same or different, each is a straight- or branched-chain alkylene or alkenylene group, and n and m, which may be the same or different, each is zero or 1, with the proviso that when A is methylene group or n is zero, m is 1; and pharmaceutically acceptable salts thereof. These compounds have a strong inhibitory effect on thromboxane synthetase from rabbit platelet microsomes, and are useful as therapeutically active agents for the treatment of inflammation, hypertension, thrombus, cerebral apoplexy and asthma.
REFERENCES:
patent: 3531494 (1970-09-01), Adolphi et al.
Ajisawa Yukiyoshi
Akahane Kenji
Iizuka Kinji
Kamijo Yukio
Momose Den-ichi
Bond Robert T.
Kissei Pharmaceutical Co. Ltd.
Ono Pharmaceutical Co. Ltd.
Randolph John D.
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