Imidazole-containing peptides having immunomodulatory activity

Details Imidazole-containing peptides having immunomodulatory activity Imidazole-containing peptides having immunomodulatory activity

1989-12-01

1993-04-13

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, A61K 3702, C07K 508

Patent

active

052023125

ABSTRACT:
Imidazole-containing peptide of the formula: ##STR1## wherein R.sup.1 is a branched alkyl group, a branched alkyloxy group or an aryl-substituted lower alkyloxy group, R.sup.2 and R.sup.4 are the same or different and each is hydrogen atom or a lower alkyl group, R.sup.3 and R.sup.5 are a phenyl-substituted lower alkyl group, R.sup.6 is hydrogen atom or a lower alkoxycarbonyl group, R.sup.7 is hydrogen atom or a nitrogen-containing heterocyclic group-substituted lower alkylthio group, X.sup.1 and X.sup.2 are the same or different and each is ##STR2## A is a lower alkylene group which may be substituted with a substituent selected from the group consisting of a lower alkoxy group, hydroxymethyl group and a group of the formula: ##STR3## and R.sup.8 and R.sup.9 are the same or different and each is hydrogen atom or a lower group, or a pharmaceutically acceptable salt thereof, which is useful as an immunomodulator and as an agent for the treatment and/or prophylaxis of autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, systemic lupus erthematodes, glomerulonephris, rhumatic fever or type I diabetes and atopic allergy, a processes for the preparation thereof, and a pharmaceutical composition containing said compound as an active ingredient.

REFERENCES:
patent: 4048305 (1977-09-01), Molteni et al.
patent: 5051441 (1991-09-01), Matsumoto et al.
Mizel et al., Proc. Natl. Acad. Sci. USA, vol. 78, No. 4, pp. 2474-2477, 1981.
Nagai et al., Japan, J. Pharmacol., 32, 1117-1124 (1982).
Sochynsky et al., Pharma Projects, vol. 7, May 1986.
Gordon et al., Journal of Leukocyte Biology, vol. 42, pp. 197-203; (1987).

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